FAQs
Combinatorial Chemistry
- What are SynPhase™ Lanterns?
- What are the physical dimensions of SynPhase™ Lanterns?
- What is the fundamental difference between SynPhase™ Lanterns and Polystyrene Resins?
- Are there any special storage requirements with SynPhase™ Lanterns?
- What is the typical loading capacity of SynPhase™ Lanterns?
- What linkers are available with SynPhase™ Lanterns?
- How does the performance of SynPhase™ Lanterns compare to polystyrene resins?
- Does polystrene resin chemistry transfer directly to SynPhase™ Lanterns?
- What solvents are compatible with SynPhase™ Lanterns? What are the swelling characteristics of SynPhase™ Lanterns in various solvents?
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What are the recommended volumes and concentrations of reagents for use with SynPhase™ Lanterns?
SynPhase Lanterns require relatively small working volumes, typically 250µL for SynPhase L-Series Lanterns and 500µL for SynPhase D-Series Lanterns. However, the actual working volume is dependent upon the shape of the reaction vessel used for synthesis.
Since SynPhase Lanterns require minimal volumes of solvent, reagent concentrations can be kept relatively high in order to quickly drive reactions to completion. Based upon the nominal loading capacity and recommended working volumes, the number of µmol and the number of equivalents for a given concentration can be derived for SynPhase Lanterns, as shown in the Table below.
As with resins, the reagent concentration (or the number of equivalents) can vary widely depending on the nature of the chemistry. When the optimum reaction conditions are unknown, we suggest that 3 different concentrations are used during the optimization, spanning the concentration range 0.1M to 2M.Recommended Volumes and Concentrations Reagent Concentration (M) L-series D-series A-series No. umol per 250uL Equiv's per Lantern No. umol per 500mL Equiv's per Lantern No. umol per 1000mL Equiv's per Lantern 0.1 25 1.67 50 1.43 100 1.34 0.2 50 3.33 100 2.86 200 2.67 0.3 75 5 150 4.29 300 4.0 0.35 87.5 5.83 175 5.0 350 4.67 0.5 125 8.33 250 7.14 500 6.67 1 250 16.7 500 14.3 1000 13.33 2 500 33.3 1000 28.6 2000 26.67 - What synthesis strategies can be used with SynPhase™ Lanterns?
- Can SynPhase™ Lanterns be used in solution phase applications?
- Is there a SynPhase™ Lantern suitable for hydrophilic applications?
- Can SynPhase™ Lanterns be used in automated synthesizers?
- How does the cost of SynPhase™ Lanterns compare to resin(s)?