FAQs
Combinatorial Chemistry
- What are SynPhase™ Lanterns?
- What are the physical dimensions of SynPhase™ Lanterns?
- What is the fundamental difference between SynPhase™ Lanterns and Polystyrene Resins?
- Are there any special storage requirements with SynPhase™ Lanterns?
- What is the typical loading capacity of SynPhase™ Lanterns?
- What linkers are available with SynPhase™ Lanterns?
- How does the performance of SynPhase™ Lanterns compare to polystyrene resins?
- Does polystrene resin chemistry transfer directly to SynPhase™ Lanterns?
- What solvents are compatible with SynPhase™ Lanterns? What are the swelling characteristics of SynPhase™ Lanterns in various solvents?
- What are the recommended volumes and concentrations of reagents for use with SynPhase™ Lanterns?
- What synthesis strategies can be used with SynPhase™ Lanterns?
- Can SynPhase™ Lanterns be used in solution phase applications?
- Is there a SynPhase™ Lantern suitable for hydrophilic applications?
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Can SynPhase™ Lanterns be used in automated synthesizers?
The compatibility of SynPhase Lanterns in automated systems is primarily dependent upon the physical dimensions of the reaction vessel of the synthesizer.
Whilst the Lanterns are compatible with a wide range of solvents and chemistries, some swelling and distortion of the Lanterns may occur, particularly in some solvents at elevated temperatures, see Table 4.
As with resin, allowance may need to be made for the change in the physical dimensions as a result of swelling of the SynPhase Lantern. Therefore provided that the reaction vessel of the synthesizer is capable of holding a 5 to 6.5mm diameter cylindrical object with a height of 5 to 6.5mm (SynPhase L-Series Lantern) or 12.5 to 16.3mm (SynPhase D-Series Lantern) then SynPhase Lanterns will be physically compatible with that equipment.Vigorous agitation is not required with SynPhase Lanterns as reactants in solution will diffuse rapidly throughout the grafted polystyrene matrix. Whilst SynPhase Lanterns are stable to stirring, agitation and ultrasonics, these techniques are not required as a general procedure. In the cases where an automated synthesizer includes provision for stirring, we would only recommend its use at low speeds where the stirrer does not physically contact the solid support or alternatively where the stirring method involves the agitation of the reaction vessel by gentle shaking.
A number of laboratories are routinely using SynPhase Lanterns in a range of commercially available synthesizers including those from Advanced ChemTech, Myriad, Bohdan and Argonaut.
- How does the cost of SynPhase™ Lanterns compare to resin(s)?