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Operating Parameters

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Solvation characteristics
Recommended volumes and concentrations
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Solvation Characteristics

Solvent wetting is much faster in SynPhase Lanterns than for resins due to the very low cross-linking of the grafted polymer surface. Consequently, SynPhase Lanterns do not need to be presoaked before synthesis. The two principal polymer types are optimized for different solvent conditions. Polystyrene (PS) requires non-polar solvents such as dichloromethane (DCM) or solvent blends, such as (DCM/DMF). Polyamide (PA) requires polar or aqueous solvents eg. DMF or water. The physical properties of SynPhase Lanterns ensure compatibility with most solvents at temperatures in the range of -80°C to +100°C. The maximum recommended temperature for use of Lanterns under any conditions is +100°C.

For swelling characteristics of SynPhase Lanterns for particular solvents, see Table 4, p5 of the SynPhase Technical Note STN001.


Recommended volumes and Concentrations

SynPhase Lanterns require relatively small working volumes and consequently, reagent concentrations can be kept relatively high in order to quickly drive reactions

to completion. Based upon the nominal loading capacity and recommended working volumes, the number of μmol and the number of equivalents for a given concentration can be derived for SynPhase Lanterns, as shown in the table below.

Recommended Volumes and Concentrations
Reagent Concentration (M) L-series D-series A-series
No. umol per 250uL Equiv's per Lantern No. umol per 500mL Equiv's per Lantern No. umol per 1000mL Equiv's per Lantern
0.1 25 1.67 50 1.43 100 1.34
0.2 50 3.33 100 2.86 200 2.67
0.3 75 5 150 4.29 300 4.0
0.35 87.5 5.83 175 5.0 350 4.67
0.5 125 8.33 250 7.14 500 6.67
1 250 16.7 500 14.3 1000 13.33
2 500 33.3 1000 28.6 2000 26.67



There are no special requirements for short-term storage. SynPhase Lanterns can be kept in their original vacuum sealed ziplock bag. However, for prolonged storage, we recommend that SynPhase Lanterns be kept cool and dry at 8°C. The storage container must always be kept tightly closed when cold and must be allowed to reach room temperature before opening to prevent condensation. SynPhase Lanterns should only be used with dried solvents in dry glassware and apparatus. Avoid rough handling or abrasion of the dry Lanterns.

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