Peptides and Peptidomimetic Synthesis
|
||
|
Synthetic peptides at the preclinical stage are primarily used for immunology or drug discovery research. One of the most useful ways of answering questions about the effectiveness of a peptide vaccine or drug is via peptide libraries. Mimotopes are leading experts at designing and providing custom peptide libraries for this purpose. These libraries are made at Mimotopes on D-series PA Lanterns, providing unparalleled efficiency and reliability in manufacture.
For chemists wishing to synthesise their own peptides, SynPhase combinatorial offers a range of Lanterns featuring a low loading polyamide graft. These have been specially optimized to prevent secondary structure formation during chain growth.
Peptide libraries can be manufactured efficiently with automated synthesisers. Alternatively, the SynPhase Workstation offers a highly effective and relatively inexpensive means to processing large numbers of Lanterns using the Multipin Array synthesis approach.
Immunological Applications
Peptide libraries are an excellent tool for mapping epitopes on antibodies or T-cells. The general strategy is to make a collection of short sequence peptides that gradually span the relevant portion of the known protein sequence by small residue increments. Subsequent assay will determine which of those peptides represents the antigen for the target sequence.
Mimotopes can assist customers with designing epitope mapping libraries. They can also provide further modifications to your peptides, such as conjugation or services such as affinity purification.
Drug Discovery Applications
The growing importance of peptides as therapeutics underpins the need for an efficient means to elucidating target sequences in biological systems. Again, peptide libraries provide this tool, offering an expedient way to generate large numbers of analogs and determine their structure activity relationships.
Here, the typical strategy involves systematic replacement of each residue in the known target sequence with substitute amino acids. This approach has proven to be effective in the discovery of cell signalling peptides and protease development, to name a few.