B-cell epitope mapping
Epitope mapping using libraries of overlapping synthetic peptides is the most efficient way to identify the linear antigenic determinants defined by a particular serum or monoclonal antibody. A convenient way to perform ELISA uses Biotinylated PepSets. The biotin coupled peptides are immobilized on plates coated with avidin or streptavidin and are then probed with antibody.
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Antibody Defined Linear Epitope Mapping
An epitope, or antigenic determinant, was defined as the site on an antigen at which an antibody binds, by virtue of the antibody's antigen-combining site
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Antibody Epitope Mapping using Biotinylated PepSets
Sets of overlapping peptides from potential target vaccine proteins can be screened with immune sera or cells to find vaccine or diagnostic test candidates, saving years of expensive “trial and error” research based on predictive methods.
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Discontinuous B-cell epitope mapping
CLIPS™ Technology Makes Discontinuous Epitopes Conform
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